Because a marked diminution of tremor of hands and fingers was noticed in a diabetic receiving tolbutamide, the authors began to use tolbutamide in patients with paralysis agitans. The studies have been continued for a year and a half, and the results have been observed in 15 patients. Eleven of the patients showed considerable reduction of tremor or rigidity or both. In several there was a marked improvement in the mask-like facies, with return of a more normal smile. In several patients, improvement of speech was noted. Care was taken to minimize the psychic effect of a new drug. It was determined that the improvements were not related to hypoglycemia. The significance of these findings is not clearly understood, but the results are consistent and indicate the need for further research on man and animals.
Gates EW, Hyman I. USE OF TOLBUTAMIDE IN PARALYSIS AGITANSPRELIMINARY REPORT. JAMA. 1960;172(13):1351–1354. doi:10.1001/jama.1960.03020130009003
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