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August 25, 1962

The Thymus, Manganese, and Myasthenia Gravis

JAMA. 1962;181(8):734. doi:10.1001/jama.1962.03050340072025

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The opening chapter on the anatomy, embryology, pathology, and physiology of the thymus is the basis for the section on myasthenia gravis, in which emphasis is placed on the clinical state, pathological picture, and various forms of therapy. A portion is devoted to the role of manganese in human and animal metabolism. Five case histories of myasthenia gravis are presented to demonstrate the author's theory of the efficacy of manganese in treating this disease. The last portion of the monograph brings forth the relationship of this disease to the other endocrine glands and to additional neuromuscular diseases.

The critical reader will immediately take issue with Josephson's opening remarks. "This study offers a clinical solution of the problem of myasthenia gravis and of kindred ailments, and sheds light on the function of the thymus and its disorders. It offers a specific remedy for those ailments." The claim is made that manganese

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