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September 1, 1962

Oxacillin: Laboratory and Clinical Evaluation

Author Affiliations

From the Department of Medicine, University of Washington School of Medicine.

JAMA. 1962;181(9):739-744. doi:10.1001/jama.1962.03050350001001

Oxacillin, one of the hundreds of new penicillins synthesized in the past few years, was compared with other penicillins in the laboratory and in patients. Five to 8 times as active as methicillin against penicillinase-producing staphylococci in vitro, oxacillin was well absorbed by the oral route, though less regularly than phenethicillin. Oxacillin showed good bactericidal activity against staphylococci and other gram-positive pathogens, but was more highly bound by serum proteins than was methicillin. Clinical results in 68 patients were good, and the authors conclude that, where oral therapy is feasible, oxacillin is a potent agent for treating infections caused by penicillin G-resistant staphylococci. Side effects were minimal.