Two women, aged 49 and 39 years, had persistent fever, marked eosinophilia (33 to 39%), and roentgenographic evidence of ill-defined, shifting infiltrations in the lungs. Biopsy specimens were obtained in both instances. In the former case the most striking lesion was an infiltration of lobular septums and of the perivascular adventitia with eosinophils; in the other case the findings included a similar infiltration, which formed small masses of the type seen in lobar pneumonia. The first patient made a complete recovery after the biopsy. In the second patient the administration of 20 mg. of prednisone twice daily promptly abated the fever and caused the eosinophilia to disappear within one day's time.
Christoforidis AJ, Molnar W. EOSINOPHILIC PNEUMONIAREPORT OF TWO CASES WITH PULMONARY BIOPSY. JAMA. 1960;173(2):157–161. doi:10.1001/jama.1960.03020200029008
Customize your JAMA Network experience by selecting one or more topics from the list below.