The question whether the habitual use of soap on the skin has any favorable or unfavorable influence on the course of eczematous eruptions led to this study of 250 patients. Of these, 246 were available in a final assessment of over-all impression of improvement after five weeks of standard therapy. During this period, 124 had regularly used the same common brand of toilet soap for routine hand washing and bathing while the others had not. The four groups of patients (with neurodermatitis, dermatitis venenata, infantile eczema, and eczematous hand dermatitis) differed in their responsiveness to treatment, dermatitis venenata being the most responsive, and infantile eczema the most refractory, but in none of the four groups was there a significant difference between those who used the soap and those who did not.
Stoughton RB, Potts LW, Clendenning W, Fisher S, Kress M. MANAGEMENT OF PATIENTS WITH ECZEMATOUS DISEASESUSE OF SOAP VERSUS NO SOAP. JAMA. 1960;173(11):1196–1198. doi:10.1001/jama.1960.03020290022004
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