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Article
August 13, 1960

LONG-TERM PRESERVATION OF BLOOD

JAMA. 1960;173(15):1668. doi:10.1001/jama.1960.03020330036012

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Abstract

Medical scientists and physicians interested in transfusion problems have worked hard to find ways of storing blood for months or years rather than for the current three or four weeks. Effective stockpiling of the large amounts of blood needed for the armed forces and the general population in the event of a nuclear attack would then become possible. Blood banks could accumulate rare types of blood and improve their ability to meet special demands, like those of open heart surgery. To date, only minor improvements have resulted from changes in the composition of solutions of anticoagulants and preservatives. Freezing of red blood cells, which has seemed the most promising attack, has been studied on a limited scale by many workers. The technical difficulties, however, are formidable: Formation of ice crystals during freezing and thawing must be avoided or cells will be damaged; glycerolization of erythrocytes has been found to prevent

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