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This symposium is a comprehensive review of the mechanisms and management of edema by over 100 investigators and clinicians. Since edema is not a problem peculiar to any one specialty in medicine, the authors comprise internists, pediatricians, surgeons, obstetricians, pharmacologists, physiologists, and biochemists.
The symposium is composed of three main parts. The initial chapters deal with the basic physiology of fluid and electrolyte balance as it pertains to the mechanisms of edema. The complex interrelationships of the kidneys, adrenals, liver, lymphatics, and the cardiovascular system are discussed at length. This is followed by several chapters on the pharmacological and clinical applications of the diuretic agents. The mechanisms, uses, and efficacy of the xanthine diuretics, mercurial diuretics, triazine compounds, and the carbonic anhydrase inhibitors are discussed. Considerable attention is centered on the thiazide derivatives. The diuretic effects of the digitalis glycosides and adrenal steroids are mentioned as well as the new
Darby R. Edema: Mechanisms and Management. A Hahnemann Symposium on Salt and Water Retention. JAMA. 1960;173(15):1765. doi:10.1001/jama.1960.03020330133035
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