Twenty-five years ago the recent advances in surgery of the heart and large blood vessels performed today could not have been foretold. The surgeon had to await appropriate developments in anesthesia, physiology, and mechanical engineering. Today, major surgery on the heart of infants is successfully carried out, and the damaged arteries of adults are replaced. What further progress will come in the next quarter of a century, likewise, cannot be foretold. An inkling, however, of what may be in store has appeared in experiments on artificial hearts that are aimed to permanently replace irreparably sick human hearts. Investigators in the Department of Artificial Organs and the Division of Research at the Cleveland Clinic Foundation and the Frank E. Bunts Educational Institute performed an experiment1 in which a mechanical heart sustained the circulation of a dog for five hours during which blood pressure, spontaneous respiration, and corneal, wink, and tendon reflexes
EXPERIMENTS ON ARTIFICIAL HEARTS. JAMA. 1960;174(2):177. doi:10.1001/jama.1960.03030020065023
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