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September 17, 1960

Diagnostic Criteria For Electrophoretic Patterns of Serum and Urinary Proteins in Multiple Myeloma: Study of One Hundred and Sixty-five Multiple Myeloma Patients and of Seventy-seven Nonmyeloma Patients with Similar Electrophoretic Patterns

Author Affiliations

Rochester, Minn.

From the Mayo Clinic and Mayo Foundation.

JAMA. 1960;174(3):245-251. doi:10.1001/jama.1960.03030030025005

Of 165 electrophoretic patterns of serum proteins in 165 patients with multiple myeloma, 126 were considered diagnostic of "myeloma proteins" because either the abnormal protein component in the pattern had a height:width ratio of 4:1 or greater, with the method used, or had a significant peak of height:width ratio of 3:1 or greater with an electrophoretic mobility faster than that of gamma globulin. By these criteria, 30 additional patterns were definitely abnormal, though not diagnostic, while only 9 were regarded as essentially normal. Thirty-seven of 62 urine electrophoretic patterns had a significant abnormal globulin component. No patient with multiple (disseminated) myeloma had a normal serum electrophoretic pattern in the absence of proteinuria. Only 15 of 6,051 serum electrophoretic patterns in non-myeloma patients were indistinguishable from the typical pattern of multiple myeloma. These included macroglobulinemia, amyloidosis, and lymphoma.