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September 17, 1960

Acute Versenate NephrosisOccurring as the Result of Treatment for Lead Intoxication

JAMA. 1960;174(3):263-269. doi:10.1001/jama.1960.03030030043008

A 1-year-old girl with acute lead poisoning developed anuria and uremia five days after treatment with calcium versenate (125 mg. per kilogram of body weight daily for three days). Her clinical course was complicated by pneumonia, pericarditis, and bleeding from the gastrointestinal tract. Despite artificial dialysis she died after remaining anuric for 13 days. At autopsy the kidneys showed acute tubular necrosis, which was attributed to the calcium versenate therapy. It is recommended that the dosage of calcium versenate should not exceed 75 mg. per kilogram of body weight.