Acquired hypogammaglobulinemia has been described for the first time as a cause of repeated infections of various types in children. The cases here described differed from classic congenital agammaglobulinemia in certain respects: (1) 5 of 17 patients were female; (2) all responded to antigenic stimulation; (3) all had normal isohemagglutinins; and (4) all improved dramatically with small doses (2.0 to 4.0 cc. every four weeks) of gamma globulin in a concentration of 165 mg. of gamma globulin per cubic centimeter of solution. Cessation of therapy after one to two years was followed by the maintenance of normal gamma globulin levels and continued clinical improvement in all but one patient. Sixteen of 17 patients had a strong personal or family history of allergy, and this association had not been previously described. Since many severely allergic children have normal gamma globulin levels, the exact significance of these findings is still a matter for speculation.
Benjamin D. Gordon, Samuel Spencer. HypogammaglobulinemiaCommon Variant in Children Responsive to Therapy. JAMA. 1960;174(3):269–272. doi:10.1001/jama.1960.03030030049009
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