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October 1, 1960

Comparison of a Tranquilizer and a Psychic Energizer: Used in Treatment of Children with Behavioral Disorders

Author Affiliations

Redondo Beach, Calif.

From the Geller Clinic for Neurology and Psychiatry.

JAMA. 1960;174(5):481-484. doi:10.1001/jama.1960.03030050023006

Seventy-five hyperactive, poorly integrated children were divided into groups of 25 for a comparative study of the effects of two drugs on their behavior. One group received a psychic energizer (deanol) in doses of 50 mg. twice daily; the second received a sedative (trimeglamide) in doses of 250 mg. twice daily; the third received a placebo. Systematic observations were made before and after the period of medication. Analysis of the results showed that deanol generally increased the child's power of concentration as manifested in integrative tasks such as puzzle-solving. Trimeglamide generally alleviated tantrums and diffuse hyperactivity. The placebo group did not manifest either of these effects. The author suggests the concomitant use of these two drugs in overly aggressive, emotionally disturbed children.