Of 338 pathologically verified bone tumors in children, 145 were benign and 193 malignant. The following procedures for diagnosis and treatment were recommended: every child with persistent pain (often referred), swelling, or limitation of motion of a skeletal part should be roentgenologically studied immediately; if the location of a radioresistant bone tumor permits, the type is best determined by biopsy distal to two tourniquets; fresh frozen specimens are examined by an experienced pathologist; and if osteogenic sarcoma or fibrosarcoma is present, amputation should be undertaken promptly. The over-all survival rate of 18.1 per cent in the treatment of 106 osteogenic sarcomas supports the plan as outlined.
Rowland SA, Dahlin DC, Hayles AB, Sullivan CR. Diagnosis and Treatment of Bone Tumors in Children. JAMA. 1960;174(5):489–491. doi:10.1001/jama.1960.03030050031008
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