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October 1, 1960

Diagnosis and Treatment of Bone Tumors in Children

JAMA. 1960;174(5):489-491. doi:10.1001/jama.1960.03030050031008

Of 338 pathologically verified bone tumors in children, 145 were benign and 193 malignant. The following procedures for diagnosis and treatment were recommended: every child with persistent pain (often referred), swelling, or limitation of motion of a skeletal part should be roentgenologically studied immediately; if the location of a radioresistant bone tumor permits, the type is best determined by biopsy distal to two tourniquets; fresh frozen specimens are examined by an experienced pathologist; and if osteogenic sarcoma or fibrosarcoma is present, amputation should be undertaken promptly. The over-all survival rate of 18.1 per cent in the treatment of 106 osteogenic sarcomas supports the plan as outlined.