Stuart Lindsay, Professor of Pathology at the University of California School of Medicine, has reviewed the clinical and pathological findings of 293 patients with carcinoma of the thyroid observed between 1920 and 1954.1 Although the complete delineation of the natural history of malignant tumors of the thyroid is not possible in this generation because of the multifaceted approach to the treatment of neoplasms, a great mass of data is presented in the monograph. Thyroid carcinoma, as defined by Lindsay, is an abnormal proliferating growth of thyroid epithelium, usually locally infiltrating the thyroid glandular parenchyma and eventually extending beyond the thyroid either by direct invasion or by lymphatic and vascular dissemination. Localized lesions were classified as malignant when the histological features were similar to or identical with those of neoplasms which possessed obvious invasive or disseminating characteristics.
The unequal sex ratio of thyroid malignancies, 3.5:1 in favor of the female,
CARCINOMA OF THE THYROID GLAND. JAMA. 1960;174(8):986. doi:10.1001/jama.1960.03030080048012
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