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October 29, 1960

Heparin Versus Heparin-Bishydroxycoumarin Anticoagulant TherapyComparison in Patients with Acute Complicated Myocardial Infarction

JAMA. 1960;174(9):1157-1160. doi:10.1001/jama.1960.03030090013003

Thrombotic complications dominated in the group treated with bishydroxycoumarin (12, compared to 5 in the heparin group). Embolic complications predominated in those treated with heparin (five, compared to one in the bishydroxycoumarin group). Of 52 patients receiving adequate bishydroxycoumarin therapy, 16 died; 8 in the group of 12 died while receiving inadequate therapy. Of 75 with adequate heparinization, 16 died; 12 out of 25 died with inadequate heparin therapy. Three or more complications were followed by death in 11 of 19 given bishydroxycoumarin and 14 of 60 given heparin.