Thrombotic complications dominated in the group treated with bishydroxycoumarin (12, compared to 5 in the heparin group). Embolic complications predominated in those treated with heparin (five, compared to one in the bishydroxycoumarin group). Of 52 patients receiving adequate bishydroxycoumarin therapy, 16 died; 8 in the group of 12 died while receiving inadequate therapy. Of 75 with adequate heparinization, 16 died; 12 out of 25 died with inadequate heparin therapy. Three or more complications were followed by death in 11 of 19 given bishydroxycoumarin and 14 of 60 given heparin.
Griffith GC, Zinn WJ, Engelberg H, Dooley JV, Anderson R. Heparin Versus Heparin-Bishydroxycoumarin Anticoagulant TherapyComparison in Patients with Acute Complicated Myocardial Infarction. JAMA. 1960;174(9):1157–1160. doi:10.1001/jama.1960.03030090013003
Customize your JAMA Network experience by selecting one or more topics from the list below.