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October 29, 1960


G. H.
JAMA. 1960;174(9):1198-1199. doi:10.1001/jama.1960.03030090054016

Farmer, Cooper, and Pascuzzi,1 in an article currently appearing in the Archives of Internal Medicine, discuss disease states characterized by the presence of a cold-precipitable serum globulin. Wintrobe and Buell in 1933 observed in a 56-year-old patient with multiple myeloma that the serum formed a viscid layer when cooled to 4† C., and that a suspension of white material developed which dissolved when the serum was warmed to room temperature. This patient had a total serum protein of 11.9 Gm./100 ml. He had symptoms suggestive of Raynaud's disease, which it was thought were related to the concentration of abnormal globulin. The term "cryoglobulin," derived from the Greek "kryos" meaning cold, was given to this protein by Lerner and associates in 1947. They described a patient with cardiovascular renal disease and a cryoglobulin concentration of 800 mg./100 ml. serum who had purpura when exposed to cold. They believed the cryoglobulin

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