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September 8, 1962

Gas Gangrene Following an Intramuscular Injection of Concentrated Liver Extract: Report of Case with Fatal Termination by Fulminating Clostridium perfringens Bacillus Septicemia

Author Affiliations

Danville, Ill.

JAMA. 1962;181(10):901-903. doi:10.1001/jama.1962.03050360087019b

THE APPEARANCE of gas gangrene at sites of parenteral injections is truly unique. A careful survey of world medical literature reveals that a total of 117 instances of gas gangrene from parenteral injections has been reported to date. An initial series of 83 cases was first assembled in 1936 by Touraine, who gathered the cases from France, Germany, and Italy. A second series, comprising 30 additional cases was reported from Brazil, in 1951. Great Britain contributed 2 more cases during 1946 and 1956 respectively, and Australia reported 1 case in 1957. No record of any instance of gas gangrene from a parenteral injection has appeared in American medical literature prior to the recent case by Koons and Boyden, published during January, 1961.

Herewith, is presented what is believed to be the second case of gas gangrene following parenteral injection to be reported in the United States, despite the fact that