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November 19, 1960

Status of Human Plasma as a Plasma Volume Expander

Author Affiliations

U. S. Army

Chief, Surgical Research Branch, Army Medical Research and Development Command.

JAMA. 1960;174(12):1617-1624. doi:10.1001/jama.1960.63030120001012

Review of Plasma Studies  Although transfusions of plasma were suggested, they were not tried as substitutes for blood transfusions during World War I. Numerous studies of plasma were made during the period between World War I and World War II, but most of them are not particularly relevant to this report. Wartime enthusiasm for the use of plasma began in 1939 when Tatum and associates1 recommended it as "an ideal substitute for whole blood in emergency treatment of shock and hemorrhage from war wounds." During subsequent months, others echoed these recommendations. In 1945, DeBakey and Carter2 commented that the misconception concerning plasma as a "blood substitute" became so widespread and so firmly entrenched in the minds of both administrative and professional personnel that it impeded the organization and the development of more effective measures for the management of shock.The first lesson to be learned, then, was that,

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