Pseudoalbuminuria in conjunction with the use of orally administered gallbladder contrast media, as first reported by Seedorf and others in 19501 and in subsequent papers,2-5 is well established. The introduction of a new contrast medium, bunamiodyl (Orabilex) and its adoption for general use in our hospital in 1959 prompted the present study. The chemical formula of bunamiodyl is 3(3-butyrylamino-2,4,6-triiodophenyl)-2-ethyl sodium acrylate. It contains 57% iodine in organic form. It is somewhat soluble in water, and excretion is largely renal.
A series of 100 patients was tested. Menstruating women, as well as patients with true albuminuria and urinary infections, were excluded. The standard dosage for each patient was 6 capsules (4.5 Gm.) of bunamiodyl. Inasmuch as the routine laboratory procedure in this hospital for detection of albumin is the use of sulfosalicylic acid and effervescent base, this was the method chosen. A solution of 4 tablets dissolved in 30
John H. Grimm, Grover C. Wallace, Barry E. Gerald. Pseudoalbuminuria Due To Bunamiodyl. JAMA. 1960;174(12):1638–1639. doi:10.1001/jama.1960.63030120015021a