Although great strides have been made in furthering our understanding of the origin of cancer, the chief forms of therapy continue to be surgery, irradiation, and treatment with hormonal methods. Advances have been made in endocrine therapy, notably by Huggins and others in the control of prostate cancer and male and female breast cancer through endocrine manipulation.1-5
In the modern era, with the advent of nuclear energy, investigators throughout the world have been on the lookout for new types and sources of irradiation for use in the treatment of patients with cancer. For over 10 years our group has been interested in a special type of radiation generated by the 184-inch cyclotron—particulate radiation, such as protons, deuterons, and alpha particles, accelerated to exceedingly high energies. These radiations have unusual characteristics in their great powers of penetration and their small degree of scatter compared with the conventional x- and gamma-radiation.
John D. Constable, John H. Lawrence, James L. Born, Cornelius A. Tobias, Piero E. Ariotti, Francesco F. Sangalli, Richard C. Carlson, Paul Toch. Effect of Alpha Particle Hypophysectomy on Disseminated Cancer of Male Breast. JAMA. 1960;174(13):1720–1723. doi:10.1001/jama.1960.63030130004012