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December 3, 1960

The Value of Corticosteroids (Corticoids) in Allergic DiseasesPractical Considerations

JAMA. 1960;174(14):1801-1809. doi:10.1001/jama.1960.03030140023005
Abstract

Adrenal corticoids are valuable for short-term use in acute or subacute allergies (e.g., status asthmaticus, serum or drug allergy, severe urticaria and angioedema, allergic dermatitis). They are also valuable for long-term use in chronic intractable asthma, making useful citizens of asthmatic cripples. They have but little value and only temporary effects in other allergies (e.g., allergic rhinitis, hay fever, chronic urticaria). In 34 of the author's patients, the corticoids have been used continuously for periods up to 7 years. In a double-blind study of 40 patients, triamcinolone seemed superior to prednisone. In general the author believes that the newer corticoids (methylprednisolone, triamcinolone, and dexamethasone) are better than the older ones, but he considers corticoid therapy an adjunct to, not a substitute for, the usual treatment of allergies.

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