The diagnosis of cerebral disorders in infants is delayed and restricted in accuracy by the developmental status of the infant brain. Knowledge is limited of structures responsible for the obliteration of infantile reflexes. There is a long delay in expression of lesions relating to sensation, intellect, and the functions of the basal ganglia. Diagnosis is made difficult by the physiological simplicity of immature nervous structures, which limits the differences in mode of expression that would distinguish the normal from the abnormal brain. It is recommended that such tests as the ferric chloride test for phenylpyruvic oligophrenia be done routinely.
Ellwood PM. Cerebral Lesions in Infancy. JAMA. 1960;174(15):1958–1961. doi:10.1001/jama.1960.03030150046012
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