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December 10, 1960

Parkinson's Disease

JAMA. 1960;174(15):1962-1965. doi:10.1001/jama.1960.63030150001013
Abstract

IN NO OTHER FIELD of neurology has the search for the pathology, pathophysiology, and anatomy so consistently failed of its objectives, after decades of investigation, as in Parkinson's disease. Significant understandings have nevertheless derived from the efforts. These will be presented after we define what is meant by Parkinson's disease, since it seems to mean so many different things to different people. Moreover, because Parkinson's disease is a grave and growing problem to society and physicians throughout the world, it is important that it be clearly understood. It is also important that it be clearly defined, in order to set a straight path for research workers engaged in finding the cause, prevention and cure.

A variety of syndromes that have nothing whatever to do with Parkinson's disease have been lumped together under this designation, to compound ignorance upon confusion. Parkinson's disease, moreover, is often referred to as "Paralysis Agitans," a

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