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December 24, 1960


JAMA. 1960;174(17):2146-2147. doi:10.1001/jama.1960.03030170036008

TO bring to patients the full benefit of the basic advances in medicine requires the continuing development of precise and specific diagnostic methods. This axiom is well exemplified by the measurement of the activities of serum enzymes in diagnosis. Among those investigated the activities of glutamic oxalacetic and glutamic pyruvic transaminase (GOT and GPT) and lactic dehydrogenase (LDH) have been studied and used most extensively. The most significant initial diagnostic impact of both assays affected the detection of acute myocardial infarction.1, 2,3 Since then, however, these enzymatic activities have been employed in the diagnosis of a wide range of clinical problems. Such studies have given rise to the rather striking generalization that the finding of an elevated serum LDH activity signifies the existence of a serious disease. Elevations of the serum LDH activity do not occur in normal persons, and abnormalities in this measurement are even more unique in

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