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September 15, 1962

Clinical Science

JAMA. 1962;181(11):972-978. doi:10.1001/jama.1962.03050370040009

Urinary Lactic Dehydrogenase Activity  I. Screening Method for Detection of Cancer of Kidneys and BladderWarren E. C. Wacker, M.D., and Lionel E. Dorfman, M.D., BostonLACTIC DEHYDROGENASE ACTIVITY (LDH) X has been reported to be present in urine,1-3 but its presence has not previously been utilized in diagnosis. LDH activity in serum and other body fluids, such as pleural effusions and ascitic fluid, however, has been used widely in the diagnosis of a large number of diseases including acute myocardial infarction,4,5 pulmonary embolism,6,8 and cancer.7,8 The present study demonstrates that an increased LDH activity in urine provides a potent diagnostic screening method for detection of malignant tumors of the kidneys and bladder.The present successful development of an adequate method for measurement of LDH activity in urine depended upon recognition and elimination of substances that inhibit LDH activity and that have been found in all