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December 31, 1960

An Introduction to Human Blood Groups

JAMA. 1960;174(18):2245. doi:10.1001/jama.1960.03030180065030

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This brochure is essentially an attempt to explain Fisher's "synthesis" of 6 blood factors, C-c, D-d, E-e, and to demonstrate its validity. The supposed discovery of anti-d by several independent workers is cited as proof of the correctness of Fisher's prediction that it would be found. Then, after the reader is convinced, the author confesses that these reports were incorrect, and that anti-d has actually not been found. He fails to point out that as many as 18 Rh-Hr factors are known at present, nor does he attempt to reconcile this with Fisher's synthesis of only 6 (or 5?) factors. While a simplified introduction to this complex subject would be welcome, this brochure, which misrepresents the facts and thus leaves the reader with dangerous misconceptions, does not fill the bill and therefore is not recommended.

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