Many of the health problems which still confront us are not understood in the fundamental terms required for design of adequate, effective means for their eradication. Cancer is of course one of the major diseases in this category. While a maximum effort is being made to provide the needed understanding of basic mechanisms responsible for the malignant process, at present only early detection of the cancer followed by its complete removal offers the opportunity of cure. Hence, the application of fundamental knowledge to provide diagnostic methods for the detection of cancer, particularly in asymptomatic persons, is an important aspect of clinical research.
Carcinomas of the kidney and bladder are notorious, and their notoriety is emphasized by their silence. Nearly one-half of the cases are recognized when it is too late for curative therapy to be attempted. A simple means to detect these cancers at a time when they are asymptomatic
URINARY LACTIC DEHYDROGENASE ACTIVITY. JAMA. 1962;181(11):990. doi:10.1001/jama.1962.03050370058013
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