[Skip to Content]
[Skip to Content Landing]
September 15, 1962


JAMA. 1962;181(11):991-992. doi:10.1001/jama.1962.03050370059016

Professor Trousseau of Paris credited Graves of Meath Hospital, Dublin, with the initial description of exophthalmic goiter, just as he believed Addison responsible for the initial description of systemic symptoms of chronic adrenal insufficiency. The identification in the first instance remained unchallenged until Osler suggested that hyperthyroidism had been noted in 1786 by Caleb Hillier Parry, a colleague of Edward Jenner. The case report was not published until his posthumous writings appeared in 1825, a decade before Graves' clinical lectures were delivered. The Germans prefer to call the malady von Basedow's disease (1840) in honor of their landsman. Earlier in the century, Flajani (1802) and Demours and Scarpa (1821) had recognized the symptom complex. Nor should one claim priority for any of these observations. A clinical malady with such distinctive features as exophthalmic goiter, which includes tachycardia, nervousness, protruding eyes, and enlarged thyroid, most surely had not escaped the attention