For more than a decade our group at New York University has been studying specific amino acid requirements of the infant. When we started this work, our philosophy about nutritional requirements was somewhat different from what it is today and the task of obtaining significant information appeared far simpler. Nutrient requirements were thought of as fixed guide posts. All one had to do was to evaluate them and assay the food; then one would know just how much food was needed to meet nutrient requirements.
In intervening years, much has been learned about interrelationships between amino acids and vitamins and between the amino acids themselves. The term amino acid imbalance has entered our vocabulary. We have learned how the concentration of one amino acid may affect the requirement of another by sparing or by competition in biological processes. We also have begun to think of optimal nutrition as not just
Holt LE, Snyderman SE. Report to the Council The Amino Acid Requirements of Infants. JAMA. 1961;175(2):100–103. doi:10.1001/jama.1961.63040020001006
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