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January 21, 1961

Atrial Septal Defect: An Investigation into the Natural History of a Congenital Heart Disease

JAMA. 1961;175(3):261. doi:10.1001/jama.1961.03040030085035

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This monograph presents a comprehensive survey of the medical and surgical literature on various forms of atrial septal defect. The embryology, pathology, and physiology are considered briefly, and then an extensive and detailed analysis of two groups of cases is presented. The first group is composed of 190 autopsy cases compiled from the literature (1811 to 1958), and is presented primarily with respect to incidence, prognosis, cause of death, and autopsy findings. The second group, consisting of 132 consecutive cases of atrial septal defects studied by the author, provides the basis for a detailed clinical and physiological presentation, with additional information concerning the effect of the lesions on the growth and physical development of the patients. The presentation is lengthy in relation to the material discussed, but the monograph represents a valuable reference source for the physician with specialized interest in congenital heart disease. The authors' findings agree with those

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