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February 11, 1961

Fatal Reaction to Sulfobromophthalein Sodium in a Patient with Bronchial Asthma

JAMA. 1961;175(6):506-508. doi:10.1001/jama.1961.63040060012021c

Despite EXTENSIVE USE of sulfobromophthalein sodium (Bromsulphalein) for testing hepatic function, only a few severe toxic reactions, 3 of them fatal, have been reported since 1948. The subject of the present report is a fatal reaction in a patient with bronchial asthma.

Report of a Case  A 51-year-old radio and television repairman was admitted to the hospital because of dyspnea. He had lived in Alabama prior to entering the Army in January of 1944. Little was known regarding his parents; his sister suffered from "asthma," and he recalled his nose "running all the time" and "breaking out in a rash" on proximity to tomato plants, as a child. Later he was treated twice for syphilis with "shots" without adverse reactions.In 1945, while with the army in England, he was hospitalized for bronchitis and pleurisy for 3 months. He apparently recovered without sequelae and had no other illnesses, but

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