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September 15, 1962

The Pluricausal Cardiopathies; the Beaumont Lecture

JAMA. 1962;181(11):1015. doi:10.1001/jama.1962.03050370083025

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It is well known that some people suffer from heart disease which is the conjoint effect of more than one cause. Heart disease in one individual due to arterial hypertension plus coronary artery disease or due to rheumatic fever plus thyrotoxicosis are clinical examples. Because of his complexity, the interrelationship between these various factors is difficult to define in man. Recourse must be had to the experimental animal in whom the conditions of observation can be fixed with considerable precision.

The present volume, an expansion and elaboration of the author's earlier ideas expressed in "The Chemical Prevention of Cardiac Necroses," is a detailed exposition of the author's researches in this field. It is intended both for the clinician and the experimental pathologist.

The work is principally concerned with the rat. Selye has shown how the concerted effect of a number of manipulations, some obligatory, some conditional and including changes in

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