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February 11, 1961

Hypoplastic Anemia

JAMA. 1961;175(6):529. doi:10.1001/jama.1961.03040060103036

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To the Editor:—  A 19-year-old Canadian worker who had been exposed to paints and solvents for at least a year showed marked pallor and hemosiderotic tinge. The liver was felt 2 fingerbreadths below the costal margin; the spleen was not palpable. Blood tests showed the following findings: hemoglobin level, 5 Gm.%; red blood cell count, 1,770,000 per cubic millimeter; white blood cell count, 1,250, with 2% band forms, 21% neutrophils, and 77% lymphocytes; and platelets, 45,000 per cubic millimeter ( measured by the direct method ). Repeated bonemarrow aspirations and one surgical biopsy specimen showed severely hypoplastic bone marrow. The serum iron level was 227 mcg.%. The serum contained agglutinins against homologous white cells and platelets at a titer of 1/32 and 1/128 respectively. There were no incomplete or coating antibodies against homologous red cells. The patient had received at least 200 transfusions over the past three years.One hundred mg. of

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