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February 25, 1961

Carcinoma in Situ of the Uterine Cervix: A Study of 235 Cases from the Free Hospital for Women

JAMA. 1961;175(8):731. doi:10.1001/jama.1961.03040080087032

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The authors present a comprehensive story of carcinoma in situ. The case histories were presented previously in two published reports in 1949 and 1951. In that this is a retrospective study, it was not possible to obtain new pathologic material, although new and serial sections were cut from existing blocks and old tissue was reblocked. A diagnosis of carcinoma in situ was made in 127 of the 235 patients in the series, and the tumors were classified as carcinoma in situ with (1) surface involvement, (2) glandular involvement, and (3) stromal invasion.

These lesions are described in great detail and illustrated in numerous excellent photographs. Short abstracts of typical histories are presented. A diagram illustrates the interrelationships of the various benign and malignant prickle cell hyperplasias. The clinical findings concerning age, symptoms, appearance of cervix, location of lesion, results of Schiller tests, findings on colposcopy, marital history, racial incidence, and

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