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To the Editor:—
I have noted the increasing use of the specific glucose oxidase method for determining the presence of glucose in urine samples sent for routine examination. The conventional screening test (Clinitest or Benedict's test) for ascertaining the presence of reducing substances in urine is important for detecting the presence not only of glucose but also of other chemicals, including galactose, other carbohydrates, amino acids, etc. While we embrace the availability of the glucose oxidase method as an advance, it is a step backward if it is used as the only test for ascertaining the presence of reducing substances. A screening test which indicates the presence of a reducing substance should be performed first, and then, if a reducing substance is present, tests to identify the substance(s) should immediately be performed on the same urine.It behooves the directors of clinical laboratories to make sure that the pendulum has
Keitel HG. Specific Glucose Oxidase Test. JAMA. 1961;176(1):72. doi:10.1001/jama.1961.03040140074026
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