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April 15, 1961

Vitamins and Hormones XVII

JAMA. 1961;176(2):171. doi:10.1001/jama.1961.03040150087035

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Volume 17 of "Vitamins and Hormones" adheres to the high standards and follows the pattern of its predecessors: research workers review fields in which they have an active interest. Metabolism of the pterins and pteridines, including folic acid, is lucidly and comprehensively presented. The term "pterinoid" is proposed for compounds with the pterin ring skeleton, by analogy with "steroid" and "carotinoid." Developments of the past 10 years in the chemistry of the K vitamins are succinctly presented. The structural differences between the K vitamins, in relation to their biological properties and to menadione, are described. In a comprehensive chapter the role of hepatic glucose-6-phosphatase in the regulation of carbohydrate metabolism is discussed. Among many interesting aspects are endocrine influences, genetic defects, and neoplasia in relation to activity of this enzyme. Under the topic "biochemistry of serotonin and other indoleamines," clinical, pharmacologic, and physiologic implications of serotonin are also presented. Ergothioneine,

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