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April 29, 1961

Thyrocardiac Disease and Its Management with Radioactive Iodine I131

Author Affiliations

New York City

From the Department of Medicine, the Thyroid Clinic and the Andre Meyer Department of Physics, The Mount Sinai Hospital.

JAMA. 1961;176(4):262-267. doi:10.1001/jama.1961.03040170008003

Hyperthyroidism was treated with I131 in 1,603 cases. These included cases of diffuse toxic goiter and nodular goiter with hyperthyroidism. There were 187 patients with congestive heart failure, 30 with angina pectoris, and 32 with combined angina pectoris and congestive failure. In addition, there were 107 patients with atrial fibrillation but without congestive failure or angina. Radioiodine was the only treatment used for the hyperthyroid state. The cardiac status was strikingly improved in all groups studied. The number of treatments and incidence of myxedema was almost the same for the cardiac and noncardiac patients. The total administered dose averaged 7.0 millicuries for the entire series and 11.5 for the cardiac patients. The recurrence rate was less than 1%. The authors believe that I131 is the treatment choice for thyrocardiac disease.