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June 10, 1961

The Acid-Consuming Capacity of Magnesium Trisilicate

JAMA. 1961;176(10):889. doi:10.1001/jama.1961.03040230055019

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To the Editor:—  In the January 21 issue of The Journal, page 267, an unfortunate error of a consultant has been compounded by repetition of his previous remarks in connection with the neutralizing capacity of magnesium trisilicate.Dr. Silverman was perfectly correct in calling attention to the error often cited that "1 gm. of magnesium trisilicate (U.S.P.) will neutralize about 155 ml. of 0.1 N hydrochloric acid." This is incorrect and has been perpetuated in the references cited by the consultant and in many other works on the subject. Simple reference to the U.S.P.will show that these figures are based on anhydrous magnesium trisilicate and not the official preparation which may contain up to 34% water.In the interest of accuracy, I suggest that you have Dr. Lloyd Miller, Director of Revision of the U.S.P., or a consultant of his choice in the chemical or drug field, arbitrate this matter.

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