In studying a single case of the idiopathic variety of diabetes insipidus, it was found that hydrochlorothiazide, after a short latent period, brought about a marked reduction in urinary output. The patient, a 45-year-old woman, had been treated for diabetes insipidus for more than 6 years, but the antidiuretic action of injected vasopressin tannate had become unpredictable and its local side effects were the cause of concern. Orally administered hydrochlorothiazide (200 mg. per day) reduced her mean daily urinary volume to 5,520 cc. Electrolyteloading tests indicated that electrolyte alterations were not responsible for this action. After several months of treatment, a reduced dosage continued to be effective.
Calesnick B, Brenner SA. An Observation of Hydrochlorothiazide in Diabetes Insipidus. JAMA. 1961;176(13):1088–1091. doi:10.1001/jama.1961.03040260022005
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