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July 1, 1961

Effect of Phenazocine on Respiration

JAMA. 1961;176(13):1092-1095. doi:10.1001/jama.1961.03040260026006

The authors investigated the claim that phenazocine in effectively analgesic doses depresses respiration less than do equally analgesic doses of morphine. The subjects were 10 normal young men and 11 older patients with cardiovascular, pulmonary, or hepatic disease. In addition to the respiratory rate a number of other criteria of ventilatory activity were used, including the response to inhalation of 4% and 6% CO2 in air. It was found that 4 mg. of phenazocine depressed the respiration more profoundly than did 15 mg. of morphine or 1.5 mg. of oxymorphone.