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July 29, 1961

Iproniazid Ointment

JAMA. 1961;177(4):276. doi:10.1001/jama.1961.03040300048018

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To the Editor:—  In The Journal of May 20 (176:646, 1961), Dr. Louis Byrne questioned whether or not the topical application of iproniazid ointment can accelerate normal wound healing, and cited as reference my paper entitled "Newer Concepts of Amine Oxidase Inhibitors," which was published in the Archives of Internal Medicine (107:37 [Jan.] 1961).In my paper I referred only to the stimulating effect observed following the local application of 2% to 5% iproniazid ointment on the delayed healing of idiopathic ulcers that may complicate rheumatoid disease or pyoderma gangrenosa accompanying chronic ulcerative colitis. In most instances, healing of these lesions occurs slowly, but, nevertheless, iproniazid is usually effective when other therapeutic measures have failed. A similar effect has not been observed in diabetic ulcers, or in those that complicate chronic venous insufficiency. This observation was first reported in the Cleveland Clinic Quartely (25:92-94 [April] 1958).

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