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August 19, 1961

Infectious Mononucleosis Complicated by Chronic Thrombocytopenia

JAMA. 1961;177(7):515-516. doi:10.1001/jama.1961.73040330028011d

INFECTIOUS mononucleosis associated with thrombocytopenia was first described by Minot1 in 1929. Since then, numerous case reports2,3 of this phenomenon have appeared in the medical literature. The majority of patients recovered from the complicating thrombocytopenia within 6 weeks, and none had depressed platelet counts after 6 months. It is the purpose of this article to present the first reported case of chronic thrombocytopenia secondary to infectious mononucleosis.

Report of a Case  An 18-year-old male was admitted to the U.S. Naval Hospital, Philadelphia, on June 17, 1958, because of petechiae and lymphadenopathy. Twelve days previously, while taking a shower, he noted petechiae on the dorsum of both feet and on his ankles. The next day he noted generalized atraumatic ecchymosis. These symptoms were succeeded by bilateral submandibular lymphadenopathy. The patient denied exposure to drugs or toxic chemicals. No previous history of hemorrhagic phenomena was elicited. He did not have