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To the Editor:—
The answers given by each of 2 consultants to a question on nonvisualization of a kidney on excretory urography (JAMA175:830 [March 4] 1961) contain statements which require clarification:1. Both consultants state that the renal excretion of indigo carmine proceeds by means of glomerular filtration. The exact method of excretion of this dye in the human has not been worked out. However, judging from its pattern of excretion in other mammals, its secretion in aglomerular fish, and its tendency to be bound to serum protein, there is much more justification in assuming its tubular secretion than in assuming its glomerular filtration. Actually, since the questioner does not state which dye was used, the assumption that indigo carmine was the agent in question seems unwarranted.2. The first consultant states that the organic iodide used in intravenous urography is secreted mainly by the renal tubules, and
Howard M. Pollack. Nonvisualization of Kidney. JAMA. 1961;177(11):813–814. doi:10.1001/jama.1961.03040370075023