THE DEVELOPMENT of malignant gliomata in patients with tuberous sclerosis is an occasional feature of this hereditary disease.1 Recently 2 patients in the same family who had tuberous sclerosis and intraventricular astrocytomas were reported.2 Ependymoma3 and spongioneuroblastomas4 also have been found in patients with this disease. However, those patients with tuberous sclerosis who have symptoms of intracranial neoplasm usually develop these symptoms because of critically situated cortical and subependymal nodules characteristic of this disorder.5
Pulmonary,6 renal,7 and osseous manifestations8,9 of tuberous sclerosis have been described in addition to the classical triad of epilepsy, mental retardation, and adenoma sebaceum. Knowledge of the wide-spread involvement and of the various clinical syndromes due to tuberous sclerosis has made it possible to diagnose this disease correctly and more frequently.
Blindness secondary to retinal gliomatous tumors known as phacomas has been observed.10 Also blindness might be
Rudnick PA, Hoshino N, Kitaoka T, Miura M. Tuberous Sclerosis Complex and Astrocytoma: Report of a Case with Successful Removal of the Neoplasm. JAMA. 1961;178(1):73–75. doi:10.1001/jama.1961.73040400026017d
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