MRL/41, an analogue of the nonsteroid estrogen, chlorotrianisene, was evaluated in the human female because it was shown to possess pituitary gonadotropin-inhibiting and antifecundity properties in rats. Although structurally related to a hormone-like chemical agent, this compound does not exhibit estrogenic, progestogenic, or androgenic activity in the human. Studies with this drug were initiated primarily because of its potential as an antifertility agent. Contrary to expectations, some unsuspected and interesting biological activities were observed, one of which was the induction of ovulatorytype menses in amenorrheic anovulatory females.
Greenblatt RB, Barfield WE, Jungck EC, Ray AW. Induction of Ovulation with MRL/41Preliminary Report. JAMA. 1961;178(2):101–104. doi:10.1001/jama.1961.03040410001001
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