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October 28, 1961

THE PHYSIOLOGY OF CARDIAC MUSCLE

JAMA. 1961;178(4):416. doi:10.1001/jama.1961.03040430052015

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Abstract

A symposium in the May issue of the American Journal of Medicine covers the current state of our knowledge of the physiology of cardiac muscle in great detail. New techniques as well as new concepts have enabled scientists to study aspects of the problem undreamed of 2 or 3 decades ago. From electron microscopic studies Stenger and Spiro believe that the myofibril is an ordered, integrated system composed of thick and thin myofilaments which interdigitate and support the view of a "sliding model" of muscular contraction. Green and Goldberger stress the close relationship between structure and function in energy production by the heart and show that through investigation of electron transport the concept of organized enzyme systems essential to the understanding of muscle contractility has emerged.

Olson, a biochemist, is primarily interested in the contractile proteins of heart muscle. These are myosin, actin, and tropomyosin. Myosin, the main constituent of

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