LONG-TERM survival of tissue transplanted from j one individual to another has rarely been observed, except in cases of identical twins. In most instances, homotransplanted tissue survives from 1 to 3 weeks and is then rejected by the host. It is now generally agreed that rejection of tissue represents an immune reaction. This conclusion is supported by the observation that a second transplant of tissue from the same donor is rejected at a more rapid rate than the first, indicating that the first transplant confers a certain degree of immunity.1 The immunity resulting from transplantation of one type of tissue will affect subsequent transplants of other tissues from the same donor. For example, if a homograft of skin is performed subsequent to the rejection of a renal homograft from the same donor, the skin graft will be rejected as rapidly as if the first transplant had been skin.2
Jordan GL, Cunningham DS, Deere H, Tullos H, Gyorkey F. A Study of Factors Affecting the Fate of Parathyroid Transplants in the Rat. JAMA. 1961;178(5):488–490. doi:10.1001/jama.1961.73040440006007b
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