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November 4, 1961

A Study of Factors Affecting the Fate of Parathyroid Transplants in the Rat

JAMA. 1961;178(5):488-490. doi:10.1001/jama.1961.73040440006007b

LONG-TERM survival of tissue transplanted from j one individual to another has rarely been observed, except in cases of identical twins. In most instances, homotransplanted tissue survives from 1 to 3 weeks and is then rejected by the host. It is now generally agreed that rejection of tissue represents an immune reaction. This conclusion is supported by the observation that a second transplant of tissue from the same donor is rejected at a more rapid rate than the first, indicating that the first transplant confers a certain degree of immunity.1 The immunity resulting from transplantation of one type of tissue will affect subsequent transplants of other tissues from the same donor. For example, if a homograft of skin is performed subsequent to the rejection of a renal homograft from the same donor, the skin graft will be rejected as rapidly as if the first transplant had been skin.2

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