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November 18, 1961


JAMA. 1961;178(7):754-755. doi:10.1001/jama.1961.03040460062014

In the article entitled "Immunization of Preschool Children with Oral Poliovirus Vaccine (Sabin)" by Dr. Horstmann et al., which appears in this issue of The Journal (p. 693), she and her colleagues describe their experience with oral poliovirus vaccine given according to 3 different dosage schedules to preschool children in the city of New Haven, Conn. This age-group, which is hard to reach for immunization, particularly in the lower socioeconomic levels, proved to be vulnerable in that city's epidemic of 1959, and in epidemics in other cities in the United States during 1959 and 1960. Experience has indicated that the preschool group is difficult to immunize not only from an administrative public health standpoint but also from a biologic standpoint, since the capacity of the 6-week- to 4-year-old child to produce and to maintain antibodies under the stimulus of killed virus vaccine alone is less than that of children of