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December 16, 1961

Effect of Pressor Amines on Myocardial Blood Flow in the Dog: Quantitative Evaluation Utilizing Radiodilution Techniques

JAMA. 1961;178(11):1090-1092. doi:10.1001/jama.1961.73040500007005b

THE LACK of a precise method for quanitatively measuring myocardial blood flow has severely limited investigation of the effects of drugs and surgery on this vital segment of the circulatory system. Methods previously employed to measure coronary flow both directly and indirectly have readily apparent disadvantages. A new technique developed in our experimental laboratory can now be used to measure simultaneously total myocardial blood flow and cardiac output with the heart intact and functioning in a physiological manner. This technique involves the continuous injection of radioiodinated (I131) human serum albumin into the left atrium while separate samples of blood from the aorta and pulmonary artery are being monitored to obtain radiodilution curves.

Although various pressor amines are widely used clinically in the treatment of shock, little is known of their effect on coronary flow. Early investigators realized that these drugs caused increased myocardial flow, but they could not