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January 6, 1962

Aortic-Valve Atresia: Report of 43 Cases

Author Affiliations

F.R.C.P. (Edin.), Toronto

From the Department of Pediatrics, University of Toronto, and the Research Institute of the Hospital for Sick Children, Toronto; aided by a grant from the Ontario Heart Foundation.; Dr. Watson is now at the Department of Pediatrics, University of Mississippi Medical Center, Jackson, Miss.

JAMA. 1962;179(1):14-18. doi:10.1001/jama.1962.03050010016003
Abstract

Few chroniclers of heart disease have stressed the importance of aortic-valve atresia as a congential defect. However, at the Hospital for Sick Children, Toronto, this lesion is the most frequent cause of congestive heart failure and death in the neonatal period. In the cases presented, the average survival was 4 1/2 days, with a maximum survival of 7 1/2 months. The chief clinical features were cyanosis, dyspnea, rapidly progressive heart failure with hepatomegally, and often a gallop rhythm. Pulmonary ejection murmurs and weak peripheral pulses were both frequently noted. The x-rays showed cardiomegally with pulmonary congestion. The electrocardiogram indicated right atrial and right ventricular hypertrophy. The prognosis is at present hopeless, but it is desirable to differentiate this condition from the more easily remediable causes of neonatal distress.

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